Flea & Tick Spot On - Advantage II equivalent for large dogs. Adventure Plus contains two powerful active ingredient. Recommended by veterinarians imidacloprid attacks a flea?s nervous system to paralyze and kill it on contact before it bites your dog. The second ingredient pyriproxyfen insect growth regulator (IGR) attacks and kills flea eggs larvae and pupae to keep immature fleas from becoming biting adults.